The following meeting was co-sponsored and attended by The Stop ALD Foundation and took place February 2008 in Boston.

Wednesday, 2/6/08

6:00 Reception at the Royal Sonesta Hotel
7:00 Dinner at Dante

Thursday, 2/7/08

7:30 Introduction and Welcome, Robert Brown
7:45 Tribute to Hugo W. Moser (1924 - 2007), Florian Eichler

Genetic and Molecular Pathophysiology of ALD and AMN
Moderator: Kenneth Fischbeck

8:00 Genetics of X-ALD, David Valle
8:30 Modifier genes in X-ALD, Patrick Aubourg
8:45 Animal Models of ALD, Johannes Berger
9:15 Animal Models of AMN, Alex McCampbell
9:45 Axonal Degeneration in ALD, AMN and Related Disorders, Jack Griffin (tentative)

10:15-10:45 Discussion
10:45-11:00 Coffee

Metabolic Aspects of ALD and AMN
Moderator: Florian Eichler

11:00 Biochemistry of X-ALD, Stephen Kemp
11:30 Cholesterol Deprivation in ALD, Marc Engelen
12:00 Biophysical Properties of Very Long Chain Fatty Acids, Jim Hamilton

12:30-1:30 Lunch

1:30 Role of the Peroxisome in ALD and AMN, Steven Steinberg
2:00 Mitochondrial Dysfunction in ALD and AMN, Kirby Smith (tentative)

2:30-3:00 Discussion

Inflammatory Aspects of ALD
Moderator: Gilmore O'Neill

3:00 Microglial Apoptosis in ALD and AMN, Florian Eichler
3:30 Glycolipids, ALD and Autoimmunity, Ron Schnaar (tentative)

4:00-4:30 Coffee

4:30 Neurodegenerative Aspects of White Matter Disease, Bruce Trapp
5:00 Microglia in Experimental Models of Neurodegeneration, Joseph El Khoury

5:30-6:00 Discussion

7:00 Dinner

Friday, 2/8/08:

Therapeutic Strategies in ALD and AMN
Moderator: Ali Fatemi

8:00 Lorenzo's Oil in ALD and AMN, Gerald Raymond
8:30 Cell Based Therapies in ALD, Charles Peters
9:00 Approaches to Gene Therapy of the CNS, Miguel Esteves
9:30 Gene Therapy in ALD and AMN, Nathalie Cartier

10:00-10:30 Discussion
10:30-11:00 Coffee

11:00 Immunomodulatory Strategies in MS, Samia Khoury
11:30 Modifiers of Oxidative Stress in ALD, Katherine Sims

12:00-12:30 Discussion

12:30 Lunch